Effects of qianggu electuary on ovariectomized osteoporotic rats.
- Author:
Tao PENG
1
;
Mang-li HUANG
;
Wei XIONG
;
Lan WANG
;
Yan-ping YANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Density; drug effects; Calcium; blood; Drug Combinations; Drugs, Chinese Herbal; isolation & purification; pharmacology; Estradiol; blood; Femur; physiopathology; Osteoporosis; blood; pathology; physiopathology; Ovariectomy; Plants, Medicinal; chemistry; Rats; Rats, Wistar; Stress, Mechanical
- From: China Journal of Chinese Materia Medica 2003;28(10):970-973
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effects of qianggu electuary (QGE), a Chinese herbal preparation, on ovariectomy-induced osteoporotic rats.
METHODFemale Wistar rats were ovariectomized and administered QGE, calcium gluconate (CG) and longmu zhuanggu granules (LMZG) for 12 weeks. Bone mineral density (BMD), indexes of biomechanics and serum E2, Ca were detected in grouped rats including QGE, CG, LMZG and control groups.
RESULTQGE could significantly increase the BMD and maximum load, maximum stress YP-load of femora in the osteoporotic rats. The values of E2 in ovariectomized osteoporotic rats decreased, compared with those of control normal rats (P > 0.05), while in the QGE treated rats, the values of E2 increased.
CONCLUSIONQGE can increase the BMD and improve indexes of bone biomechanics in ovariectomized osteopotic rats, possibly due to its estrogen-like effect.
