Protective effect of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury in rats.
- Author:
Zhi-peng WANG
1
;
Li LIU
;
Qi-bing MEI
;
Rong ZHANG
;
Jian-wen GU
;
Xiang ZHANG
;
Da-kuan GAO
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Brain Injuries; enzymology; metabolism; pathology; Cerebral Cortex; enzymology; ultrastructure; Male; Malondialdehyde; metabolism; Neuroprotective Agents; pharmacology; Plants, Medicinal; chemistry; Polysaccharides; isolation & purification; pharmacology; Rats; Rats, Sprague-Dawley; Rheum; chemistry; Sodium-Potassium-Exchanging ATPase; metabolism; Superoxide Dismutase; metabolism
- From: China Journal of Chinese Materia Medica 2003;28(10):974-971
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate protective effects of Rheum tanguticum polysaccharides (RTP) on traumatic brain injury (TBI) in rats.
METHODThe polysaccharides (RTP) were extracted from Tanguficum Maxim. 120 rats were divided into 15 groups, with 8 rats in each group. RTP at 100, 200 and 400 mg x kg(-1) were administrated orally once a day for five days, and model of brain injury was made by dropping weight method.
RESULTRTP reduced water content and malondialdehyde (MDA) levels, and increased total SOD activity and Na+-K+ ATPase activity after injuried.
CONCLUSIONThe polysaccharides may be one of the effective comptents in Rheum tanguticum, showing significant neuroprotective effects.
