Effect of the sustained release excipients on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax notoginsenosides.
- Author:
Qing WU
1
;
Xian-chun CHEN
;
Shou-ying DU
Author Information
- Publication Type:Journal Article
- MeSH: Chemistry, Pharmaceutical; Delayed-Action Preparations; Drugs, Chinese Herbal; administration & dosage; Excipients; chemistry; Ginsenosides; chemistry; Lactose; analogs & derivatives; chemistry; Methylcellulose; analogs & derivatives; chemistry; Oxazines; Panax; Plants, Medicinal; Tablets
- From: China Journal of Chinese Materia Medica 2004;29(10):944-947
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the influence of the sustained release excipient on the release rate of ginsenoside Rg1 and ginsenoside Rb1 in sustained-release tablet of Panax Notoginsenosides.
METHODThe release rate of ginsenoside Rg1 and ginsenoside Rb1 in different matrix tablets with different excipient (HPMC, EC), different viscosity of EC (RT-50, RT-100), different ratio of EC in matrix tablet were detected.
RESULTAll above different factors influence the release rate of ginsenoside Rg1 and ginsenoside Rb1 and brought them different release curve.
CONCLUSIONEmphasis should be laid on the different release characteristic of different active compounds in active fraction.
