Effect of danshensu, protocatechualdehyde and danshen injection on calcium ion concentration in cytoplasm of human erythrocytes.
- Author:
Ling-hong SHEN
1
;
Bin-yao WANG
;
Chang-qian WANG
;
Xiu-lan XIE
;
Guo-rui YU
;
Zhong-yi YAO
;
Yuan-long ZHU
;
Bao-jin YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Benzaldehydes; isolation & purification; pharmacology; Calcium; metabolism; Catechols; isolation & purification; pharmacology; Cytoplasm; metabolism; Drug Synergism; Drugs, Chinese Herbal; isolation & purification; pharmacology; Erythrocytes; metabolism; Female; Humans; Injections; Lactates; isolation & purification; pharmacology; Male; Middle Aged; Plants, Medicinal; chemistry; Salvia miltiorrhiza; chemistry
- From: China Journal of Chinese Materia Medica 2004;29(10):984-988
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the predominant calcium-antagonist components of Danshen injection.
METHODThe effects of danshensu, protocatechualdehyde and Danshen injection on calcium concentration in cytoplasm of erythrocytes were examined in vitro by the fluorescent Ca+ -chelator fura-2.
RESULTEither DS182 or PCAD can decrease in dose-dependent cytosolic free calcium concentration in human erythrocytes. They had additive effect when mixed, which was similar to Danshen injection.
CONCLUSIONDS182 and PCAD may be predominant calcium-antagonist components of Danshen injection.
