Study on quality evaluation methods of pretreatment for polystyrene-type macroporous absorbing resins.
- Author:
Liang DENG
1
;
Li-ming YE
;
Shi-xiang HOU
;
Gang CHEN
;
Cong CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Chromatography, Gas; instrumentation; methods; Drug Contamination; Pharmaceutical Preparations; analysis; Quality Control; Resins, Synthetic; Styrene; analysis
- From: China Journal of Chinese Materia Medica 2004;29(11):1037-1040
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a GC method using wide bore open tubular columns f or controlling pretreatment for polystyrene-type macroporous absorbing resins and its eligible standard.
METHODA model macroporous absorbing resins made in our lab was eluted by anhydrous alcohol. The residual solvents in elution (xylene, styrene, diethylbenzene, divinybenzene, decane) were assayed by GC. When the residual solvents can not be detected, the pretreatment is eligible. Compare this method with the methods referring in the literatures.
RESULTWhen using this method to control the pretreatment, the resins need to be elute 11 times with anhydrous alcocol. When using "adding several times water in the alcohol elution will not be turbid" to control the pretreatment, the resins need to be elute 3 times with anhydrous alcocol. When using "the elution have no UV absorption between the wavelength 200-400 nm" to control the pretreatment, the resins need to be elute over 20 times with anhydrous alcocol.
CONCLUSIONThe method is simple and feasible.
