Expression of microRNA-31 and its clinicopathologic significance in oral squamous cell carcinoma.
- Author:
Shao-bo OUYANG
1
;
Jun WANG
;
Zi-kun HUANG
;
Lan LIAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Carcinoma, Squamous Cell; metabolism; pathology; Cell Differentiation; Female; Humans; Lymphatic Metastasis; Male; MicroRNAs; metabolism; Middle Aged; Mouth Neoplasms; metabolism; pathology; Up-Regulation; Young Adult
- From: Chinese Journal of Stomatology 2013;48(8):481-484
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of microRNA-31 and its association with clinicopathologic features in oral squamous cell carcinoma (OSCC).
METHODSThe expression level of microRNA-31 in 62 cases of OSCC and matched non-tumor adjacent tissue specimens was examined using stem-loop real-time PCR. The relationship between the expression of microRNA-31 and its clinicopathologic features of OSCC was analyzed.
RESULTSThe expression of microRNA-31 was significantly higher in the tumor tissues than that in the adjacent tissues (P < 0.05).Up-regulated microRNA-31 expression was associated with the lymph node metastasis (P < 0.05) and cell differentiation (P < 0.05) in OSCC patients.No significant association was found between the expression of microRNA-31 and gender, age, lymph node metastasis, tumor size and location.Receiver operator characteristic curve (ROC) of microRNA-31 about cell differentiation resulted in a diagnostic sensitivity of 70.4% and specificity of 89.5%.
CONCLUSIONSThe up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC.
