Expression of microRNA-31 and its clinicopathologic significance in oral squamous cell carcinoma
10.3760/cma.j.issn.1002-0098.2013.08.008
- VernacularTitle:微RNA-31在口腔鳞状细胞癌中的表达及临床意义
- Author:
Shao-Bo OUYANG
1
;
Jun WANG
;
Zi-Kun HUANG
;
Lan LIAO
Author Information
1. 330006,南昌大学附属口腔医院修复科
- Keywords:
MicroRNA;
Oral Sprays;
Cell differentiation
- From:
Chinese Journal of Stomatology
2013;48(8):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of microRNA-31 and its association with clinicopathologic features in oral squamous cell carcinoma (OSCC).Methods The expression level of microRNA-31 in 62 cases of OSCC and matched non-tumor adjacent tissue specimens was examined using stem-loop real-time PCR.The relationship between the expression of microRNA-31 and its clinicopathologic features of OSCC was analyzed.Results The expression of microRNA-31 was significantly higher in the tumor tissues than that in the adjacent tissues (P < 0.05).Up-regulated microRNA-31 expression was associated with the lymph node metastasis (P < 0.05) and cell differentiation (P < 0.05) in OSCC patients.No significant association was found between the expression of microRNA-31 and gender,age,lymph node metastasis,tumor size and location.Receiver operator characteristic curve (ROC) of microRNA-31 about cell differentiation resulted in a diagnostic sensitivity of 70.4% and specificity of 89.5%.Conclusions The up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC.