Expression of microRNA-31 and its clinicopathologic significance in oral squamous cell carcinoma

VernacularTitle:微RNA-31在口腔鳞状细胞癌中的表达及临床意义
Author: Shao-Bo OUYANG ¹ ; Jun WANG ; Zi-Kun HUANG ; Lan LIAO
Author Information

1. 330006,南昌大学附属口腔医院修复科
Keywords: MicroRNA; Oral Sprays; Cell differentiation
From: Chinese Journal of Stomatology 2013;48(8):481-484
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of microRNA-31 and its association with clinicopathologic features in oral squamous cell carcinoma (OSCC).Methods The expression level of microRNA-31 in 62 cases of OSCC and matched non-tumor adjacent tissue specimens was examined using stem-loop real-time PCR.The relationship between the expression of microRNA-31 and its clinicopathologic features of OSCC was analyzed.Results The expression of microRNA-31 was significantly higher in the tumor tissues than that in the adjacent tissues (P ＜ 0.05).Up-regulated microRNA-31 expression was associated with the lymph node metastasis (P ＜ 0.05) and cell differentiation (P ＜ 0.05) in OSCC patients.No significant association was found between the expression of microRNA-31 and gender,age,lymph node metastasis,tumor size and location.Receiver operator characteristic curve (ROC) of microRNA-31 about cell differentiation resulted in a diagnostic sensitivity of 70.4％ and specificity of 89.5％.Conclusions The up-regulated level of microRNA-31 expression may be related to the pathogenesis of OSCC.