Expressions of bFGF and PTEN in cervical carcinoma and their clinical significance.
- Author:
Chun-fang LUO
1
;
Hui-li HONG
;
Yu-lan LU
;
Hui WANG
;
Ming-qiu LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; Adult; Aged; Aged, 80 and over; Carcinoma, Squamous Cell; metabolism; pathology; Cervix Uteri; cytology; metabolism; Epithelium; metabolism; Female; Fibroblast Growth Factor 2; metabolism; Humans; Immunohistochemistry; Lymphatic Metastasis; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; PTEN Phosphohydrolase; metabolism; Uterine Cervical Neoplasms; metabolism; pathology; Young Adult
- From: Chinese Journal of Oncology 2010;32(7):533-538
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of bFGF and PTEN in cervical carcinoma and their clinical significance.
METHODSTissue microarray technique and immunohistochemistry SP method were used to detect the expressions of bFGF and PTEN in 143 cases of invasive carcinoma of cervix (ICC) and 20 cases of normal cervical epithelium remote from tumor (NCE). The relationship between the expressions of bFGF and PTEN in ICC and some factors relating to clinical pathology of cervical carcinoma such as histopathological grading, lymph node metastasis, stroma involvement and FIGO staging were analyzed.
RESULTSThe rate of the positive expression of bFGF in ICC was significantly higher than that in NCE 88.8% (127/143) vs. 25.0% (5/20, P = 0.000). The rate of positive expression of PTEN in ICC was significantly lower than that in NCE 67.1% (96/143) vs. 100.0% (20/20, P = 0.000). The expression of bFGF was positively correlated with lymph node metastasis and histopathological grading (r = 0.239, P = 0.004 and r = 0.369, P = 0.000, respectively). The expression of PTEN was negatively correlated with FIGO staging, histopathological grading and lymph node metastasis (r = -0.189, P = 0.024; r = -0.211, P = 0.011; r = -0.321, P = 0.000, respectively). The expression of bFGF was negatively correlated with the expression of PTEN in ICC (r = -0.261, P = 0.002).
CONCLUSIONThe overexpression of bFGF and underexpression of PTEN are closely related to the invasion and growth of cervical carcinoma. Detection of the expression of both bFGF and PTEN may be of value in further understanding the biological behavior and predicting the prognosis of cervical carcinoma.
