Expression and significance of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma.
- Author:
Wen-xin WU
1
;
Yin-yan DUAN
;
Gui-hua LÜ
;
Shu-fen SHI
;
Jie-ying ZHANG
;
Heng-shu WANG
;
Xiang-hong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adaptor Proteins, Signal Transducing; metabolism; Adenoma; metabolism; pathology; Adult; Carcinoma; metabolism; pathology; Cell Transformation, Neoplastic; Colorectal Neoplasms; metabolism; pathology; Female; Humans; Inhibitor of Apoptosis Proteins; metabolism; Intestinal Mucosa; metabolism; pathology; Male; Mitogen-Activated Protein Kinase 8; metabolism; Neoplasm Proteins; metabolism; Precancerous Conditions; metabolism; pathology; Proto-Oncogene Proteins c-raf; metabolism
- From: Chinese Journal of Oncology 2010;32(9):671-675
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the possible role of JNK1, Raf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma.
METHODSImmunohistochemical staining was used to detect the expression of JNK1, Raf-1 and Livin proteins in 65 sporadic colorectal tubular adenomas with dysplasia of varying degrees and 22 colorectal tubular adenoma with cancerous area.
RESULTSIn normal colorectal mucosa, colorectal tubular adenoma with dysplasia and colorectal tubular adenoma with cancerous area, the positive rate of JNK1, Raf-1 and Livin expression was increased gradually. The positive expression of JNK1, Raf-1 and Livin was all significantly higher in the cases of colorectal tubular adenoma with dysplasia or with cancerous area than that in normal colorectal mucosa (P < 0.05), and the positive expression of JNK1, Raf-1 and Livin was significantly higher in colorectal tubular adenoma with cancerous area than that in colorectal tubular adenoma with dysplasia of different degrees (P < 0.05). In the cases of colorectal tubular adenoma with dysplasia of varying degrees, the positive expression of Raf-1 was increased along with the increasing dysplasia degree of colorectal tubular adenoma (P < 0.05). Coexpression of JNK1, Raf-1 and Livin increased gradually in the carcinogenesis of sporadic colorectal tubular adenoma, while positive correlation was found among the expressions of JNK1, Raf-1 and Livin.
CONCLUSIONJNK1, Raf-1 and Livin may be involved in the carcinogenesis of sporadic colorectal tubular adenoma.
