Expression of SLP-2 protein in esophageal squamous cell carcinoma is associated with cancer invasion.
- Author:
Wen-feng CAO
1
;
Li-yong ZHANG
;
Bin ZHANG
;
Yue-qi WANG
;
Zhi-hua LIU
;
Bao-cun SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Blood Proteins; metabolism; physiology; Blotting, Western; Carcinoma, Squamous Cell; metabolism; pathology; Esophageal Neoplasms; metabolism; pathology; Female; Humans; Immunohistochemistry; Lymphatic Metastasis; Male; Membrane Proteins; metabolism; physiology; Middle Aged; Neoplasm Invasiveness
- From: Chinese Journal of Oncology 2010;32(11):830-833
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of stomatin-like protein-2 (SLP-2) in esophageal squamous cell carcinoma (ESCC), and analyze the correlation between SLP-2 expression and clinicopathological features.
METHODSThe expression of SLP-2 protein in ESCC tissues (18 and 220 cases respectively) was detected by Western blot and IHC. The association between SLP-2 expression and clinicopathological features was analyzed.
RESULTSCompared with normal epithelium, 13 cases of ESCC tissues showed a higher expression of SLP-2 on the protein level (72.2%, 13/18). IHC analysis on tissue microarray revealed that the expression rate of SLP-2 protein in ESCC was 54.1% and in normal esophageal mucosa was 3.6%, showing a significant difference (P < 0.001). SLP-2 high-level expression correlates with the extent of ESCC invasion (P = 0.033), but not with other clinicopathologic characteristics (P > 0.05).
CONCLUSIONSLP-2 as a novel cancer-related gene may play an important role in tumorigenesis of ESCC. The overexpression of SLP-2 may be closely associated with the invasion of esophageal cancer.
