Pharmacokinetics of paroxetine tablet in healthy Chinese volunteers.
- Author:
Jun ZHU
1
;
Wei-zhong LIU
;
Hong YANG
;
Wen-xian LIU
;
Hua-cheng WANG
;
Yu-hua LIN
;
Yi LIU
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Oral; Adult; Chromatography, High Pressure Liquid; Humans; Paroxetine; administration & dosage; pharmacokinetics; Serotonin Uptake Inhibitors; administration & dosage; pharmacokinetics; Tablets; Young Adult
- From: Journal of Southern Medical University 2008;28(2):260-262
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the pharmacokinetics of paroxetine tablet in Chinese healthy volunteers.
METHODSTwenty healthy subjects received a single oral dose of 40 mg paroxetine tablet. The plasma concentrations of paroxetine were determined using high-performance liquid chromatography (HPLC) and the measurements were analyzed with 3P97 program.
RESULTSThe plasma concentration curve of paroxetine following a single oral dose administration conformed to the two-compartment open model. The main pharmacokinetics parameters of paroxetine were: C(max)64.74-/+18.43 ng/ml, T(max)5.64-/+1.84 h, t(1/2) 20.03-/+5.33 h, AUC(0-120) 976.47-/+309.49 ng.h/ml, and AUC(0-inf) 1086.75-/+376.54 ng.h/ml.
CONCLUSIONThe pharmacokinetics of paroxetine in human body conforms to the two-compartment open model.
