Expression of human telomerase reverse transcriptase in renal cell carcinoma and its clinical significance.
- Author:
Peng WU
1
;
Shao-bin ZHENG
;
Yi ZUO
;
Wan-long TAN
;
Chen YAO
;
Yao-dong JIANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Biomarkers, Tumor; genetics; metabolism; Carcinoma, Renal Cell; genetics; metabolism; pathology; Female; Humans; Male; Middle Aged; RNA, Messenger; genetics; metabolism; Telomerase; genetics; metabolism
- From: Journal of Southern Medical University 2008;28(2):272-274
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of human telomerase reverse transcriptase (hTERT) in renal cell carcinoma (RCC) and its clinical significance.
METHODSThe expression levels of hTERT mRNA and protein were detected using RT-RCR and Western blotting in 45 RCC tissues, 45 adjacent tissues and 786-0 cell line, and the associations of hTERT expression with the tumor size, clinical stage, pathological type and grade were evaluated.
RESULTShTERT mRNA and protein was expressed at significantly higher levels in RCC tissues than in the adjacent tissues (P=0.000), and no correlation of hTERT expression was found with the tumor size, clinical stage, pathological type or grade.
CONCLUSIONhTERT might serve as a diagnostic and prognostic marker for RCC, and also shed light on the new clues for gene therapy of RCC.
