In vitro bactericidal activity of Jinghua Weikang Capsule and its individual herb Chenopodium ambrosioides L. against antibiotic-resistant Helicobacter pylori.
- Author:
Wei LIU
1
;
Yu LIU
;
Xue-Zhi ZHANG
;
Ning LI
;
Hong CHENG
Author Information
- Publication Type:Journal Article
- MeSH: Anti-Bacterial Agents; pharmacology; Chenopodium ambrosioides; Drug Resistance, Microbial; Drugs, Chinese Herbal; pharmacology; Helicobacter Infections; drug therapy; physiopathology; Helicobacter pylori; drug effects; isolation & purification; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Plant Preparations; pharmacology; Sensitivity and Specificity
- From: Chinese journal of integrative medicine 2013;19(1):54-57
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo investigate the bactericidal effects of Jinghua Weikang Capsule and its major component Chenopodium ambrosioides L. on antibiotic-resistant Helicobacter pylori.
METHODSFour clinical antibiotic-resistant H. pylori strains were isolated and incubated in liquid medium containing Jinghua Weikang Capsule or Chenopodium ambrosioides L. By means of time-kill curve method, the average colony counts and bactericidal rate were calculated at time points of 0, 4, 8 and 24 h after the incubation and the time-kill curves were charted.
RESULTSBoth Jinghua Weikang Capsule and Chenopodium ambrosioides L. at a concentration of 0.64 g/L showed obvious bactericidal effect against antibiotic-resistant H. pylori after 4 h of incubation.
CONCLUSIONJinghua Weikang Capsule and Chenopodium ambrosioides L. are considered to be active against antibiotic-resistant H. pylori in vitro.
