Comparative study on absorption kinetics in intestines of rats of epimedii foliunm of Xianlinggubao capsules prepared by different processes.
- Author:
Huichao WU
1
;
Yang LU
;
Shouying DU
;
Wen CHEN
;
Yue WANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Capsules; Drugs, Chinese Herbal; analysis; pharmacokinetics; Epimedium; chemistry; Flavonoids; analysis; pharmacokinetics; Humans; Intestinal Absorption; Intestines; metabolism; Male; Models, Animal; Rats; Rats, Sprague-Dawley
- From: China Journal of Chinese Materia Medica 2011;36(19):2648-2652
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the characteristics of intestinal absorption of icariin and epimedin C of Xianlinggubao capsules, and compare the absorption of Xianlinggubao capsules prepared by different processes.
METHODNon everted gut sac method was applied to investigate the influence of absorption sites and concentration on icariin and epimedin C, which were determined by HPLC.
RESULTThe absorption rate constants of epimedin C in duodenum were absolutely more than that in jejunum and ileum (P < 0.05). The absorption rate constants of icariin in jejunum were absolutely less than that in duodenum and ileum (P < 0.05). The absorption rate constants of epimedin C and icariin kept at the same level when the concentrations of drug solution were at high, middle and low level. The Ka of epimedin C at three levels were 0.040, 0.058, 0.061 h(-1) , respectively, and the Ka of icariin at three levels were 0.002, 0.007, 0.003 h(-1), respectively.
CONCLUSIONIntestinal absorption of icariin and epimedin C is not effected by concentrations. The absorption rate constants of icariin and epimedin C in new Xianlinggubao capsules are higher.
