Effects of honey to acyclovir in the rabbit eye transport kinetics.
- Author:
Qun HE
1
;
Shi WANG
;
Xianghui ZHANG
;
Jian ZHANG
;
Yu JIANG
;
Jiangli XU
Author Information
- Publication Type:Journal Article
- MeSH: Acyclovir; pharmacokinetics; therapeutic use; Animals; Antiviral Agents; pharmacokinetics; therapeutic use; Disease Models, Animal; Eye; drug effects; metabolism; Female; Honey; analysis; Humans; Keratitis, Herpetic; drug therapy; metabolism; Male; Rabbits
- From: China Journal of Chinese Materia Medica 2011;36(19):2723-2726
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEUsing pharmacokinetics to explore the mechanism of honey to enhance the efficacy of acyclovir (ACV) treatment of herpes simplex keratitis (HSK), providing the basis for combination of the prescription of two drugs and dosage regimen designed.
METHODSingle dosages of 5% honey and 0% honey Meyasu eye ointment are injected into rabbit eyes. The aqueous humor of rabbit eye is measured at different times, specifically the content of ACV in aqueous humor by HPLC. Mathematical models are established, from which pharmacokinetic parameters are extracted and compared by mathematics and statistics methods.
RESULTBoth the 5% and 0% honey Meyasu eye ointment in rabbit eyes are belong to a two-compartment model. The absorption half-life of the 5% Meyasu eye ointment in aqueous humor is as 2.30 times longer, the distribution half-life is 2.12 times longer, the peak concentration is 1.17 times longer, the peak time is 1.36 times longer, AUC is 1.41 times longer when compared to the 0% Meyasu eye ointment.
CONCLUSIONHoney can significantly increase the ACV concentration and bioavailability in the eye, extend the action time of ACV in target cells and increase the retention capacity of ACV in the target tissue; thereby improving treatment success.
