Protective effect of purslane in a rat model of ulcerative colitis.
- Author:
Yun HUANG
1
;
Lei DONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Colitis, Ulcerative; drug therapy; enzymology; genetics; pathology; Disease Models, Animal; Drugs, Chinese Herbal; administration & dosage; Humans; Male; Peroxidase; genetics; metabolism; Portulaca; chemistry; Protective Agents; administration & dosage; Rats; Rats, Sprague-Dawley; Treatment Outcome
- From: China Journal of Chinese Materia Medica 2011;36(19):2727-2730
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the protective effect of purslane on the acute injury caused by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS) in rats.
METHODSeventy-two male SD rats were separated into 6 groups randomly. Rat model of ulcerative colitis was established by intra-colonic administration of trinitrobenzenesulfonic acid (TNBS). Purslane (2.5, 5, 10 g x kg(-1)) and sulfasalazine(0.5 g x kg(-1)) was administered by enemata, 3 days after TNBS instillation and daily during 10 days before killing the rats. Colons were removed for histological analysis and measurement of myeloperoxidase (MPO).
RESULTRats treated with purslane (5 and 10 g x kg(-1)) were significantly healthier than TNBS-alone rats, as shown by improved food intake and reduced diarrhea, corrected the disorders in morphology associated to lesions, significantly reduced myeloperoxidase (MPO) levels.
CONCLUSIONpurslane exerts protective effect in experimental colitis, the effect seems to be related to relieving inflammatory reaction and repairing lesions.
