Study on rat nasal absorption in situ of borneol based on single pass perfusion method.
- Author:
Xiao SONG
1
;
Shouying DU
;
Yang LU
;
Yong MA
;
Xiaolan CHEN
;
Yue WANG
;
Huixian ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Absorption; Administration, Intranasal; methods; Animals; Bornanes; administration & dosage; pharmacokinetics; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Perfusion; methods; Rats
- From: China Journal of Chinese Materia Medica 2011;36(18):2489-2492
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the absorption characteristic of borneol.
METHODUsing single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied.
RESULTPerfusion rate on the absorption rate constants (Ka) had significant effects. Drug concentration and pH value on the absorption rate constants had no significant impact.
CONCLUSIONthe absorption of borneol is good by nasal. The absorption rate constants of borneol have no effected by drug concentration. The absorption of borneol is via a simple diffusion.
