Frequency of Granulocyte-Spedfic Anhgens among Koreans.
- Author:
Kyou Sup HAN
;
Tae Hyun UM
- Publication Type:Original Article
- MeSH:
Antibodies;
Female;
Flow Cytometry;
Fluorescent Antibody Technique, Indirect;
Gene Frequency;
Granulocytes;
Humans;
Lung;
Neutropenia
- From:Korean Journal of Blood Transfusion
1996;7(1):1-9
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Granulocyte-specific antigens, such as NA1, NA2, NBI, NB2, NC1, NDI, NE1, are a group of antigens specifically expresesed only on the granulocytes. Antibodies against these are involved in some clinical disorders such as alloimmune neonatal neutropenia(ANN), autoimmune neutropenia(AIN), and transfusion-related acute lung injury(TRALI). We investigated the frequencies of NA1, NA2, NB1, and Mart antigens among Koreans by the granulocyte indirect immunofluorescence test employing flow cytometry. The subjects were 105 Koreans(male 65, female 40), whose mean age was 31.7+/-8.2 years (range 16~57). The antigen and gene frequencies were as follows, NA1, 0.78, 0.53, NA2, 0.75, 0.50, NB1 0.86, 0.62, and Mart, 1.00, 1.00, respectively. The proportions of NB 1 -positive granulocytes among NB 1-positive individuals were variable(range, 27~100%). Through this study, the authors procured granunlocyte-specifiic antigen papnel, which is essential in the identification of causative antibody(-ies) in immune neutropenias.
