Expression of HOXC13 in ameloblastoma.
- Author:
Ming ZHONG
1
;
Jie WANG
;
Yan-bing GONG
;
Jin-cheng LI
;
Bo ZHANG
;
Lin HOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Ameloblastoma; genetics; metabolism; pathology; Female; Gene Expression; Genes, Homeobox; Homeodomain Proteins; metabolism; Humans; Male; Middle Aged; Mouth Mucosa; metabolism; Odontogenic Tumors; genetics; metabolism; RNA, Messenger; metabolism; Young Adult
- From: Chinese Journal of Stomatology 2007;42(1):43-46
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the expression of HOXC13 mRNA in ameloblastoma (AB), and to investigate its biological significance.
METHODSHOXC13 mRNA was examined in 47 cases of AB (primary AB 29 cases, recurrent AB 14 cases, malignant AB 4 cases). 2 cases of fibrous dysplasia of bone, 10 cases of keratocystic odontogenic tumor (KCOT) and 7 cases of normal oral mucosa were selected as control.
RESULTSThe positive rates of HOXC13 mRNA in AB, KCOT, and normal oral mucosa were 97.9% (46/47), 7/10 and 3/7, respectively. There was a significant difference among AB, OKC and normal mucosa (chi(2) = 21.665, P = 0.001). For HOXC13, the keratinizing cells and granulizing cells in AB were negative, some fibroblasts were positive, 2 cases of fibrous dysplasia of bone were positive.
CONCLUSIONSHOXC13 was highly expressed in AB. The expression of HOXC13 mRNA in AB had heterogeneity, which could improve the epithelial proliferation, and its loss may lead to the cornification and degeneration of epithelial cells.
