Expression of drug resistance and metastasis related gene in adenoid cystic carcinoma and mucoepidermoid carcinoma.
- Author:
Xiao-feng WANG
1
;
Yang GUO
;
Shen-shan JIA
Author Information
- Publication Type:Journal Article
- MeSH: Carcinoma, Adenoid Cystic; genetics; Carcinoma, Mucoepidermoid; genetics; Cell Line, Tumor; Drug Resistance, Neoplasm; genetics; Gene Expression Regulation, Neoplastic; Genes, MDR; Humans; Neoplasm Metastasis; genetics; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Salivary Gland Neoplasms; genetics
- From: Chinese Journal of Stomatology 2007;42(2):78-79
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo examine the differential gene expression among adenoid cystic carcinoma ACC-M, low metastasis ACC-2 and low differentiated mucoepidermoid carcinoma MEC-1 with gene array, and detect three important genes with real-time quantitative PCR.
METHODSGene array was used to screen the differential genes, then three important genes were selected and detected by real-time quantitative PCR.
RESULTSThe gene contents of MDR-1, MRP-1 and CCD1 were MEC-1 > ACC-M > ACC-2, MEC-1 > ACC-M > ACC-2 and MEC-1 > ACC-M > ACC-2 respectively.
CONCLUSIONSDrug resistance of MEC-1 is related with high content of MDR-1. High metastasis of ACC-M is concerned with high content of MRP-1 and low content of CCD-1. Low metastasis of ACC-2 has a relationship with low content of MRP1.
