Differentiation of Parkinson's Disease and Essential Tremor on I-123 IPT(I-123-N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta(4-cholorophenyl) tropane) Brain SPECT.
- Author:
Moonsun PAI
1
;
Tae Hyun CHOI
;
Sung Min AHN
;
Jai Yong CHOI
;
Won Gee RYU
;
Jae Hoon LEE
;
Young Hoon RYU
Author Information
1. Department of Nuclear Medicine, Kwandong University College of Medicine, Koyang, Korea.
- Publication Type:Original Article
- Keywords:
Dopamine transporter;
I-123 IPT SPECT;
essential tremor;
Parkinson' disease
- MeSH:
Brain;
Diagnosis, Differential;
Dopamine Plasma Membrane Transport Proteins;
Essential Tremor;
Parkinson Disease;
Tomography, Emission-Computed, Single-Photon
- From:Nuclear Medicine and Molecular Imaging
2009;43(2):100-106
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The study was to assess I-123-N-(3-iodopropen-2-yl)-2[beta]-carbomethoxy-3[beta]-(4-cholorophenyl) tropane (IPT) SPECT in differential diagnosis among early stage of Parkinson's disease(PD) and essential tremor(ET) and normal control(NL) groups quantitatively. MATERIALS AND METHODS: I-123 IPT brain SPECT of 50 NL, 20 early PD, 30 advanced PD, and 20 ET were performed at 20 minutes and 2 hours. Specific/nonspecific binding of striatum was calculated by using right and left striatal specific to occipital non-specific uptake ratio (striatum-OCC/OCC). RESULTS: Mean value of specific/nonspecific binding ratio was significantly different between advanced PD group and NL group. However, significant overlap of striatal specific/nonspecific binding ratio was observed between PD group and ET group. Bilateral striatal specific/nonspecific binding ratios were decreased in advanced PD. Lateralized differences in the striatal uptake of I-123 IPT correlated with asymmetry in clinical findings in PD group. CONCLUSION: I-123 IPT SPECT may be a useful method for the diagnosis of PD and objective evaluation of progress of clinical stages. Care should be made in the differential diagnosis of early stage of PD and other motor disturbances mimicking PD such as ET in view of significant overlap in striatal I-123 specific/nonspecific binding ratio.
