Alterations of Regional Cerebral Blood Flow in Major Depressive Disorder.
- Author:
Won Hyoung LEE
1
;
Yong An CHUNG
;
Ye Young SEO
;
Ik Dong YOO
;
Sae Jung NA
;
Hyun Suk JUNG
;
Ki Jun KIM
Author Information
1. Department of Radiology, College of Medicine, The Catholic University of Korea, Seoul, South Korea. nm@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Depression;
regional cerebral blood flow;
brain SPECT
- MeSH:
Brain;
Cysteine;
Depression;
Depressive Disorder, Major;
Diagnostic and Statistical Manual of Mental Disorders;
Frontal Lobe;
Gyrus Cinguli;
Humans;
Organotechnetium Compounds;
Perfusion;
Pons;
Tomography, Emission-Computed, Single-Photon
- From:Nuclear Medicine and Molecular Imaging
2009;43(2):107-111
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The authors analyzed how the regional cerebral blood flow (rCBF) findings of patients with major depression differ from the normal control, and our results were compared to previous reports. MATERIALS AND METHODS: Twelve patients fulfilling DSM-IV criteria for major depression who were off all psychotropic medications for >4weeks (male: 7, female: 5, age range: 19~52 years, average age: 29.3+/-9.9 years) and 14 normal volunteers (male: 8, female: 6, age range: 19~53 years, average age: 31.4+/-9.2 years) were recruited. Images of brain perfusion SPECT were obtained using Tc-99m ECD and patterns of the rCBF were compared between patients with major depression and the healthy control subjects. RESULTS: The patients with major depression showed increase of the r-CBF in right lingual gyrus, right fusiform gyrus, left lingual gyrus, left precuneus, and left superior temporal gyrus, and showed decrease of r-CBF in right pons, left medial frontal gyrus, cingulate gyrus of left limbic lobe, cingulate gyrus of right frontal lobe, and cingulate gyrus of right limbic lobe compared to the normal control. CONCLUSION: The Tc-99m ECD brain perfusion SPECT findings in our study did not differ from the previously reported regional cerebral blood flow pattern of patients with major depression. Especially, decreased rCBF pattern typical to major depression patients in the right pons, left medial frontal gyrus, and cingulate regions was clearly demonstrated.
