Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population.
- Author:
Xiao-Lan LU
1
;
Xu-Jie ZHOU
;
Jian-Ping GUO
;
Ru-Lin JIA
;
Yi ZHAO
;
Quan JIANG
;
Xiang-Yuan LIU
;
Yi LIU
;
Ling-Yun SUN
;
Hong ZHANG
;
Zhan-Guo LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Arthritis, Rheumatoid; epidemiology; genetics; Asian Continental Ancestry Group; Autophagy-Related Protein 5; Female; Genetic Predisposition to Disease; genetics; Genotype; Humans; Male; Microtubule-Associated Proteins; genetics; Middle Aged; Polymorphism, Single Nucleotide; genetics; Positive Regulatory Domain I-Binding Factor 1; Repressor Proteins; genetics
- From: Chinese Medical Journal 2011;124(18):2863-2867
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDA previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis (RA) in Caucasian populations. The aim of this study was to investigate the effect of rs548234 polymorphism at PRDM1-ATG5 region on susceptibility to RA in Chinese Han population.
METHODSWe genotyped 848 RA patients and 1431 matched healthy controls for rs548234 single-nucleotide polymorphism (SNP) with a predesigned TaqMan SNP genotyping assay. Association analyses were performed on the whole data set and on rheumatoid factors (RF) and anti-cyclic citrullinated peptides (anti-CCP) antibody. Finally, we carried out combined analysis of rs548234 association with RA based on the published data.
RESULTSNo significant difference in the genotype distribution between RA patients and healthy controls for rs548234 (C/T) polymorphism was found in Chinese Han population, neither in whole data set nor in stratified subsets, e.g. RF and anti-CCP status. Association analysis in different ethnic groups showed that rs548234 at PRDM1-ATG5 region was associated with RA in Caucasian ancestry but not in East Asian population.
CONCLUSIONSOur results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population.
