Magnetic resonance spectroscopy on hepatocellular carcinoma after transcatheter arterial chemoembolization.
- Author:
Du-Jun BIAN
1
;
En-Hua XIAO
;
Dong-Xu HU
;
Xiang-Yu CHEN
;
Wei-Jun SITU
;
Shu-Wen YUAN
;
Jian-Ling SUN
;
Li-Ping YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Hepatocellular; metabolism; therapy; Chemoembolization, Therapeutic; Choline; metabolism; Female; Glucose; metabolism; Glutamic Acid; metabolism; Glutamine; metabolism; Glycogen; metabolism; Humans; Lipids; analysis; Liver Neoplasms; metabolism; therapy; Magnetic Resonance Spectroscopy; methods; Male; Middle Aged
- From:Chinese Journal of Cancer 2010;29(2):198-201
- CountryChina
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVEProton magnetic resonance spectroscopy (MRS) of the liver in vivo is in experimental phase. MRS observation on liver cancer after transcatheter arterial chemoembolization (TACE) has seldom been reported. This study was to investigate the value of MRS in assessing the metabolic changes of hepatocellular carcinoma (HCC) after TACE.
METHODSTwenty-five consecutive patients with pathologically-confirmed HCC received 1H MRS of all hepatic lesions using 1.5T whole body MR scanner before TACE and at 3-10 days after TACE. Choline-to-lipid (Cho/Lip), glucogen/glucose-to-lipid (Glu/Lip), and glytamine/glutamate-to-lipid (Glx/Lip) ratios were measured and analyzed statistically.
RESULTSThe Cho/Lip, Glu/Lip, and Glx/Lip ratios were 0.21 +/- 0.08, 0.11 +/- 0.05, 0.28 +/- 0.10 before TACE, respectively, and were 0.10 +/- 0.08, 0.07 +/- 0.07, 0.18 +/- 0.12 after TACE, respectively, with significant differences (P < 0.05).
CONCLUSIONSUsing MRS can evaluate the early metabolic responses of HCC to TACE.
