Influence of lymph vascular space invasion on prognosis of patients with early-stage cervical squamous cell carcinoma.
- Author:
Ming YAN
1
;
Yan-Na ZHANG
;
Jie-Hua HE
;
Jin-Rui SUN
;
Xue-Ming SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Carcinoma, Squamous Cell; pathology; therapy; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Follow-Up Studies; Humans; Hysterectomy; methods; Lymph Node Excision; Lymph Nodes; pathology; surgery; Lymphatic Metastasis; Lymphatic Vessels; pathology; Middle Aged; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Pelvis; Proportional Hazards Models; Radiotherapy, Adjuvant; Retrospective Studies; Uterine Cervical Neoplasms; pathology; therapy
- From:Chinese Journal of Cancer 2010;29(4):425-430
- CountryChina
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVEIn the past decade, no remarkable improvement has been made in the 5-year survival of cervical cancer patients. This study was to explore the influence of lymph vascular space invasion (LVSI) on the prognosis of patients with early-stage cervical squamous cell carcinoma.
METHODSA total of 111 eligible patients with FIGO stage IB and IIA cervical squamous cell carcinoma underwent radical hysterectomy and pelvic lymphadenectomy at Sun Yat-sen University Cancer Center between January 1995 and December 2002. The histopathological slides of the 111 patients were reviewed by a senior gynecological pathologist. LVSI, invasion depth, tumor differentiation and lymph node metastasis were evaluated.
RESULTSLVSI was present in 62 patients. The univariate analysis showed that the risk factors of overall survival (OS) included positive LVSI (P = 0.019) and lymph node metastasis (P = 0.002), while the risk factors of progression-free survival (PFS) included LVSI (P = 0.029), lymph node metastasis (P = 0.002), SccAg value (P = 0.018), invasion depth (P = 0.022) and positive surgical margin (P = 0.002). The multivariate analysis showed that lymph node metastasis was the independent prognostic factor of OS (P = 0.015), while lymph node metastasis and positive surgical margin were the independent factors of PFS (P = 0.006, P = 0.006). LVSI was correlated with lymph node metastasis (P = 0.011).
CONCLUSIONWhether LVSI is an independent prognostic factor of early-stage cervical squamous cell carcinoma cannot be determined currently while LVSI is a risk factor of metastasis and relapse.
