Instructional significance of HBV-DNA load in maternal milk on breastfeeding of postpartum women infected with HBV.
- Author:
Jia-ying HE
1
;
Ying-hua ZHANG
;
Yong-le ZHANG
;
He-feng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Breast Feeding; DNA, Viral; isolation & purification; Female; Hepatitis B; prevention & control; transmission; Hepatitis B e Antigens; blood; Hepatitis B virus; Humans; Infectious Disease Transmission, Vertical; prevention & control; Milk, Human; virology; Viral Load; Young Adult
- From: Chinese Journal of Preventive Medicine 2011;45(11):1004-1006
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the instructional significance of HBV-DNA load in maternal milk on breastfeeding of postpartum women infected with HBV.
METHODSHBV-DNA levels in serum and breast milk were detected by FQ-PCR in 152 postpartum women infected with HBV, and HBV-DNA ≥ 1.0 × 10(3) U/ml was defined as HBV positive. Correlation analysis was also conducted to estimate if there were relations in HBV levels in serum and breast milk.
RESULTSHBV-DNA positive rate were 50.66% (77/152) and 36.18% (55/152) in serum and breast milk, respectively. When HBeAg was positive, HBV-DNA positive rate were 95.38% (62/65) and 76.92% (50/65) in serum and breast milk; however when HBeAg was negative, HBV-DNA positive rate were 17.24% (15/87) and 5.75% (5/87) in serum and breast milk. When the concentration of HBV-DNA was 3-4 lg U/ml in serum, HBV-DNA positive rate was 20.00% (5/25) in breast milk; However, when the concentration of HBV-DNA was higher than 5 lg U/ml in serum, HBV-DNA positive rate was 96.15% (50/52) in breast milk.
CONCLUSIONThe HBV-DNA level in breast milk in postpartum women infected with HBV increased with the HBV-DNA levels in serum. Breastfeeding should be avoided when the concentration of HBV-DNA is higher than 1.0 × 10(3) U/ml in milk.
