AZF microdeletions are not related with recurrent spontaneous abortion.
- Author:
Hong-Yong LU
1
;
Ying-Xia CUI
;
Xin-Yi XIA
;
Yi-Chao SHI
;
Bin YANG
;
Yong SHAO
;
Yi-Feng GE
;
Bing YAO
;
Xiao-Jun LI
;
Yu-Feng HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Habitual; genetics; Abortion, Spontaneous; genetics; Chromosome Deletion; Chromosomes, Human, Y; Female; Genetic Loci; Humans; Male; Polymerase Chain Reaction; methods; Pregnancy; Seminal Plasma Proteins; genetics
- From: National Journal of Andrology 2008;14(12):1099-1102
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between azoospermia factor (AZF) microdeletions of the Y-chromosome and recurrent spontaneous abortion.
METHODSWe collected 26 chorionic villus samples from abortive male embryos and 51 blood samples from the husbands whose wives had recurrent spontaneous abortion, extracted genomic DNA from the samples and detected 12 STSs in the AZFa, AZFb and AZFc regions of Yq11.2 by amplification multiplex PCR.
RESULTAZF microdeletions were found neither in the chorionic villus samples nor in the blood samples.
CONCLUSIONThere is no relationship between AZF microdeletions and recurrent spontaneous abortion.
