Evaluation of CD4+ CD25+ regulatory T cells in the peripheral blood of recurrent spontaneous abortion patients.

Xin-yi Xia; Bin Yang; Ting Xiong; Hong-yong LU; Yi-feng GE; Bin Yao; Ying-xia Cui; Yu-feng Huang

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Evaluation of CD4+ CD25+ regulatory T cells in the peripheral blood of recurrent spontaneous abortion patients.

Author: Xin-Yi XIA ¹ ; Bin YANG ; Ting XIONG ; Hong-Yong LU ; Yi-Feng GE ; Bin YAO ; Ying-Xia CUI ; Yu-Feng HUANG
Author Information

1. PLA Research Institute of Clinical Laboratory Medicine, School of Clinical Medicine Nanjing University Medical College, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. xiaxy@androl.cn
Publication Type:Journal Article
MeSH: Abortion, Habitual; blood; immunology; Abortion, Spontaneous; blood; immunology; Adult; CD4 Antigens; blood; Case-Control Studies; Female; Flow Cytometry; Humans; Immune Tolerance; Interleukin-2 Receptor alpha Subunit; blood; Pregnancy; T-Lymphocytes, Regulatory; immunology
From: National Journal of Andrology 2008;14(12):1106-1108
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo explore the role of CD4+ CD25+ regulatory T cells (CD4+ CD25+ Tr) in the pathogenesis of recurrent spontaneous abortion.
METHODSPeripheral blood samples were collected from 29 women with unexplainable recurrent spontaneous abortion (the URSA group) and another 20 with normal pregnancy (the control group). The percentage of CD4+ CD25+ Tr in the peripheral blood was measured by flow cytometry.
RESULTSThe rate of CD4+ CD25bright Tr in the URSA patients ([1.98 +/- 0.96]%) was significantly lower than that in the control group ([3.21 +/- 1.25]%, P < 0.05), while the percentages of CD4+ CD25+ and CD4+ CD25dim and the ratio of CD4+ CD25bright/CD4+ were not significantly different between the two groups (P > 0.05).
CONCLUSIONURSA might be associated with the decreased percentage of CD4+ CD25bright Tr, which plays an important role in fetomaternal immunologic tolerance.