Two Cases of Philadelphia Chromosome-negative Essential Thrombocythemia Manifested bcr-abl Gene Rearrangement.
- Author:
Tong Kil JUNG
1
;
Nan Young LEE
;
Jang Soo SUH
Author Information
1. Department of Clinical Pathology, School of Medicine, Kyungpook National University, Daegu, Korea.
- Publication Type:Case Report
- Keywords:
Ph chromosome-negative essential thrombocythemia;
bcr-abl rearrangement;
b3a2 transcripts
- MeSH:
Alkaline Phosphatase;
Anemia;
Diagnosis;
Gene Rearrangement*;
Humans;
Hydrogen-Ion Concentration;
Inflammation;
Leukemia, Myelogenous, Chronic, BCR-ABL Positive;
Leukocytes;
Philadelphia Chromosome;
Platelet Count;
Splenomegaly;
Thrombocythemia, Essential*
- From:Korean Journal of Clinical Pathology
2001;21(5):327-330
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Discrepant results have been reported in terms of detecting bcr-abl transcripts in patients with essential thrombocythemia that are Philadelphia (Ph) chromosome-negative. We present two cases of Ph chromosome-negative essential thrombocythemia in whom bcr-abl gene rearrangement was detected. In the diagnosis of both cases, they lacked the splenomegaly, anemia and basophilia, and had high platelet counts (948X10(3)/L and 1,329X10(3)/microL, respectively) and normal leukocyte alkaline phosphatase (LAP) scores on admission without any evidence of inflammation, infection, or therapy. They lacked the Philadelphia chromosome characteristic of classical chronic myelogenous leukemia (CML) and had b3a2 transcripts.
