Aging reduces contents of endogenous CO, cAMP and cGMP in rat penile tissues.
- Author:
Wen-Bo QIN
1
;
Shu-Qiu WANG
;
Ming LI
;
Yu-Ming KANG
;
Shi-Liang GUI
;
Bao-Jin CHI
Author Information
- Publication Type:Journal Article
- MeSH: Aging; physiology; Animals; Carbon Monoxide; metabolism; Cyclic AMP; metabolism; Cyclic GMP; metabolism; Male; Penis; metabolism; Rats; Rats, Wistar
- From: National Journal of Andrology 2009;15(2):122-125
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship of aging with the changes of endogenous carbon monoxide (CO), cGMP and cAMP contents in the penile tissues of rats.
METHODSTwenty-four male rats were equally divided into an 8-month, a 16-month and a 24-month group, and their penile erection was detected by injecting apomorphine, their penile cavernous body harvested, and the contents of CO, cAPM and cGMP detected by improved dual wavelength spectrophotometry.
RESULTSThe contents of CO, cAPM and cGMP were reduced with the increase of age, with statistically significant differences between the three age groups (P < 0.01).
CONCLUSIONAging significantly decreased the contents of CO, cAMP and cGMP in the penile tissues of the rats, which suggests that aging might play an important role in erectile dysfunction.
