Partial deletions in the AZFc region of the Y chromosome are associated with male infertility.
- Author:
Lei WAN
1
;
Zhi-Ming CAI
Author Information
1. School of Clinical Medicine, Medical College of Shantou University, Shantou, Guangdong 515041, China.
- Publication Type:Journal Article
- MeSH:
Chromosome Deletion;
Chromosomes, Human, Y;
Genetic Loci;
Humans;
Infertility, Male;
genetics;
Male;
Seminal Plasma Proteins;
genetics
- From:
National Journal of Andrology
2009;15(2):165-169
- CountryChina
- Language:Chinese
-
Abstract:
Microdeletion of the azoospermia factor in the Yq of the Y chromosome is one of the important causes of male infertility. Complete deletion of the AZFc region (b2/b4 deletion) is the most common type of AZF deletion. Recent studies have shown a variety of deletions of the AZFc region, including partial deletions, such as gr/gr deletion, b1/b3 deletion and b2/b3 deletion, which may also be associated with male infertility.
