Regulation of ion and ion channels in sperm capacitation.
- Author:
Shou-Xin ZHANG
1
;
Xiao-Yan LIU
;
Hai-Yan WANG
Author Information
1. Central Laboratory, Shandong Research Center of Stem Cell Engineering, Shandong 264000, China. 9712zhangsx@163.com
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Ion Channels;
metabolism;
Ions;
metabolism;
Male;
Mammals;
Signal Transduction;
Sperm Capacitation;
physiology
- From:
National Journal of Andrology
2009;15(2):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Ion channels in mammal sperm, including Ca2+, Na+, K+, Cl- and HCO3- channels, each play a key role in the process of sperm capacitation. Ca2+, HCO3- and ROS, as signal molecules, activate soluble adenylyl cyclase (sAC) with the cooperation of cyclic adenosine monophosphate (cAMP), Ca2+ and intracellular pH and, via a cross talk between the cAMP/protein kinase A (PKA) and tyrosine phosphatase signaling pathways, promote the biological effect of sperm capacitation.
