Study on dissoluble test for long -acting tablet of nifedipine by flow-through dissolution system
- Author:
Hue Thi Minh Pham
- Publication Type:Journal Article
- Keywords:
nifedipine
- MeSH:
Nifedipine;
tablets;
Pharmaceutical Preparations
- From:Pharmaceutical Journal
2000;291(7):20-23
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Testing of pharmaceutical dosage forms for in vitro drug release and dissolution characteristics is very important for ensuring batch-to-batch quality control and to optimize formulations during product development. The ideal system for evaluating the drug release characteristics of poorly water-soluble drug formulations (as nifedipine tablets) is to maintain “sink conditions”. Flow-through dissolution systems (e.g. USP XXIV apparatus 4) can be used to over come solubility limitations. In this study, a flow-through dissolution system was installed to evaluate two sustained release nifedipine tablets (Adalat retard 20 mg and Nifedipine retard 20 mg- Life Pharma). The dissolution profiles prove that this system with the pump rate of 14-16 ml/min offers a method to evaluate nifedipine tablets, especially sustained release formulations.
