Clinicopathological significance of gastric mucosal infection with coccoid Helicobacter pylori.
- Author:
Dongbing ZHU
1
;
Li SHA
2
;
Xiaojian SHEN
2
;
Jing HUAN
2
;
Haiyun WANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Gastritis; microbiology; pathology; Gastritis, Atrophic; microbiology; pathology; Helicobacter Infections; microbiology; Helicobacter pylori; classification; isolation & purification; Humans; Lymphocyte Count; Male; Middle Aged
- From: Chinese Journal of Pathology 2014;43(5):326-329
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the detection method of coccoid helicobacter pylori (HP) and to investigate the significance of pure coccoid HP infection of gastric mucous membrane.
METHODSA total of 171 gastric biopsy specimens were reviewed by HE stain, and the presence, density and tissue distribution of HP were investigated by sliver stain and immunohistochemistry(S-P method).
RESULTSThe rates of mucosal erosion and active inflammation with the presence of pure coccoid HP infection were 36.0% (9/25) and 44.0% (11/25), respectively, both higher than those without HP infection (13.5%, 10/74; 24.3%, 18/74), while lower than those infected with spiral HP (72.1%, 49/68; 79.4%, 54/68). The quantity of interstitial lymphocyte and inflammation severity were also higher than those without HP infection, while lower than those with spiral HP infection.
CONCLUSIONSPure coccoid HP causes human gastritis, similar to that of spiral HP infection but at a lesser degree. Further studies are important to confirm its clinical significance.
