Prognostic significance of NADPH quinine oxidoreductase 1 overexpression in head and neck squamous cell carcinoma.
- Author:
Yang YANG
1
;
Tiefeng JIN
;
Shuangping LIU
;
Liyan CHEN
;
Lijuan LIN
;
Hongxiu HAN
;
Longshan LI
;
Zhenhua LIN
2
Author Information
- Publication Type:Journal Article
- MeSH: Breast; enzymology; Carcinoma, Squamous Cell; enzymology; mortality; pathology; Disease-Free Survival; Female; Head and Neck Neoplasms; enzymology; mortality; pathology; Humans; Kaplan-Meier Estimate; NAD(P)H Dehydrogenase (Quinone); metabolism; NADH, NADPH Oxidoreductases; metabolism; Prognosis; Proportional Hazards Models
- From: Chinese Journal of Pathology 2014;43(7):463-467
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the significance of NADPH quinine oxidoreductase 1 (NQO1) protein overexpression on prognostic evaluation of head and neck squamous cell carcinoma (HNSCC).
METHODSNQO1 protein was detected in 162 of HNSCC, 45 cases of adjacent nontumor tissues and 26 samples of normal head and neck epithelia using EnVision immunohistochemical. Correlation between NQO1 overexpression and patients prognosis was also analyzed.
RESULTSThe positive rate and strongly positive rate of NQO1 protein were 84.0% (136/162) and 69.8% (113/162) in HNSCC, respectively, and both of which were significantly higher than either those in adjacent nontumor tissues and normal head and neck epithelia (both P < 0.01). NQO1 expression was significantly correlated with the clinical stage, pT and chemoradiotherapy of HNSCC (P < 0.01). Kaplan-Meier survival analysis showed that overall survival and disease-free survival rates were significantly higher in HNSCC patients with high level NQO1 expression than that those with low level of NQO1 expression (Log-rank = 6.625 , P = 0.010;Log-rank = 6.234 , P = 0.013). Additional analysis by Cox proportional hazard regression model showed that high level of NQO1 expression was an independent hazard predictor for overall survival of patients with HNSCC (Wald = 6.626, P = 0.008).
CONCLUSIONSNQO1 expression level is closely correlated with the progression and prognosis of patients with HNSCC. High level of NQO1 expression may be used as an important indicator for patients with poor prognostic HNSCC.
