Expression of Versican and its clinical significance in gastric carcinoma.
- Author:
Miling YANG
1
;
Lifeng WANG
;
Jinhua YANG
;
Guangying YANG
2
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD34; metabolism; Fibroblasts; metabolism; Humans; Immunohistochemistry; Lymphatic Metastasis; Neoplasm Proteins; metabolism; Neovascularization, Pathologic; Prognosis; Stomach; metabolism; Stomach Neoplasms; blood supply; metabolism; pathology; Vascular Endothelial Growth Factor A; metabolism; Versicans; metabolism
- From: Chinese Journal of Pathology 2014;43(7):473-477
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of Versican in gastric carcinoma and its relationship with tumor angiogenesis.
METHODSProtein expression of Versican, vascular endothelial growth factor and CD34 was evaluated by immunohistochemistry (EliVision method) in 80 cases of gastric carcinoma and 30 samples of normal gastric tissue.
RESULTSThere were statistically significant differences in the expression of Versican, vascular endothelial growth factor and CD34 between gastric carcinoma and normal gastric tissue (P < 0.05). The expression of Versican was seen mainly in fibroblasts of the tumor and was correlated with tumor differentiation, clinical stage and lymph node metastasis (P < 0.05), whereas vascular endothelial growth factor was primarily seen in the cytoplasm of the tumor cells and correlated with tumor differentiation, clinical stage, Lauren classification and lymph node metastasis (P < 0.05). MVD was correlated with tumor differentiation, clinical stage, Lauren classification, depth of tumor invasion and lymph node metastasis (P < 0.05). In addition, positive correlation of Versican and VEGF protein expression was found in tumor cells (r = 0.467, P < 0.01).
CONCLUSIONThe expression of both Versican and vascular endothelial growth factor is closely associated with tumor angiogenesis in gastric carcinoma.
