Progress in application of targeting viral vector regulated by microRNA in gene therapy: a review.
- Author:
Guohai ZHANG
1
;
Qizhao WANG
;
Jinghong ZHANG
;
Ruian XU
Author Information
1. Institute of Molecular Medicine, Huaqiao University, Quanzhou 362021, China.
- Publication Type:Journal Article
- MeSH:
Gene Expression Regulation;
Genetic Therapy;
Genetic Vectors;
genetics;
Humans;
MicroRNAs;
genetics;
Viruses;
genetics;
metabolism
- From:
Chinese Journal of Biotechnology
2010;26(6):707-714
- CountryChina
- Language:Chinese
-
Abstract:
A safe and effective targeting viral vector is the key factor for successful clinical gene therapy. microRNA, a class of small, single-stranded endogenous RNAs, act as post-transcriptional regulators of gene expression. The discovery of these kind regulatory elements provides a new approach to regulate gene expression more accurately. In this review, we elucidated the principle of microRNA in regulation of targeting viral vector. The applications of microRNA in the fields of elimination contamination from replication competent virus, reduction of transgene-specific immunity, promotion of cancer-targeted gene therapy and development of live attenuated vaccines were also discussed.
