Experimental study on the change and effect of TGF-beta 1 after skin expansion.

Author: Kai LIU ¹ ; Zhihong FAN ; Yunliang QIAN
Author Information

1. Department of Plastic Surgery, Ninth Hospital of Shanghai, Second Medical University, Shanghai 200011, China.
Publication Type:Journal Article
MeSH: Animals; Dermatologic Surgical Procedures; Immunohistochemistry; In Situ Hybridization; Rabbits; Time Factors; Tissue Expansion; Transforming Growth Factor beta; analysis; physiology
From: Chinese Journal of Plastic Surgery 2002;18(1):33-35
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the injury process of the skin due to expansion.
METHODSNew Zealand rabbits were divided into 4 groups: rapid expansion and slow expansion as well as two control groups. The changes of skin TGF-beta 1 were observed immediately after expansion and at 1, 12, 24 weeks after expansion. Immunohistochemistry and in situ hybridization technique were applied.
RESULTSTGF-beta 1 increased in the skin immediately after expansion. In groups of rapid expansion, TGF-beta 1 increased faster and then decreased also faster than slow expansion groups. The results from immunohistochemistry and in situ hybridization were almost same.
CONCLUSIONExpansion resulted in skin injury. Rapid expansion injured the skin more seriously than slow expansion. TGF-beta 1 may be the main regulating factor to repairing process.