Experimental studies on histocompatibility of three bio-derived bones.
- Author:
Zhiming YANG
1
;
Yanlin LI
;
Huiqi XIE
;
Tingwu QIN
;
Fuguo HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Antibodies; blood; Bone Transplantation; Bone and Bones; immunology; Female; Histocompatibility; Histocompatibility Testing; Male; Rabbits; Tissue Engineering
- From: Chinese Journal of Plastic Surgery 2002;18(1):6-8
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the histocompatibility of three bio-derived bones.
METHODSAfter treatment with different physical and chemical method, three bio-derived bones, the composite fully deproteinized bone (CFDB), partially deproteinized bone (PDPB) and partially decalcified bone (PDCB) were implanted into rabbits. The toxicity, immune response and subperiosteum osteogenesis of CFDB, PDPB and PDCB were studied through gross observation, serum antibody measurement, evaluation of local cellular immune response and HE staining.
RESULTSThe study showed that CFDB, PDPB and PDCB had no toxicity. They could conduct peripheral tissue to grow into them and had no harmful effect on subperiosteum osteogenesis. They could also promote cartilage and osteoid tissue derived from periosteum to calcify to new bone, and combine with the peripheral bone. The degree of immune response caused by them was in the sequence of PDCB > PDPB > CFDB.
CONCLUSIONSThe three bio-derived bones, CFDB, PDPB and PDCB have good histocompatibility.
