The characteristics of PCNA expression in hypertrophic scars and chronic ulcers and implication of the expression.
- Author:
Tongzhu SUN
1
;
Xiaobing FU
;
Xiaoman GU
;
Yinhui YANG
;
Xiaoqing SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Cicatrix, Hypertrophic; metabolism; pathology; Female; Humans; Male; Proliferating Cell Nuclear Antigen; biosynthesis; Skin Ulcer; metabolism; pathology
- From: Chinese Journal of Plastic Surgery 2002;18(4):232-233
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the characteristics of PCNA expression in hypertrophic scars and chronic ulcers and to discuss its relation to their formation.
METHODSThe expressive quantity and sites of PCNA were detected with the immunohistochemical SP method.
RESULTSPCNA was expressed in all samples. The expressive quantity in hypertrophic scars was higher than chronic ulcers(P < 0.01). The expressive sites of all samples were in the nucleus of fibroblasts and capillary endothelial cells.
CONCLUSIONSThe expressive quantity of PCNA was more in hypertrophic scars and less n chronic ulcers. The quantitative difference of expression between hypertrophic scars and chronic ulcers may be correlated to their formation.
