The effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival.
- Author:
Xukai WANG
1
;
Dong YAN
;
Yongquan LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Fibroblast Growth Factor 2; pharmacology; Graft Survival; drug effects; physiology; Male; Microscopy, Confocal; Neovascularization, Physiologic; drug effects; Rabbits; Surgical Flaps; blood supply; physiology; Time Factors
- From: Chinese Journal of Plastic Surgery 2002;18(5):278-279
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the effect of basic fibroblast growth factor (bFGF) on neovascularization and prefabricated flap survival.
METHODSMale New-Zealand rabbits weighting 2.0-2.5 kg were used in this study. The experimental model used a prefabricated neck flap, supplied by the transferred and implanted central vascular bundle of the ear. 9 micrograms bFGF and 0.2 ml of normal saline was instilled in the vascular pedicle of the experimental and the control group respectively. After 1, 2, 3 weeks of operation, the neovascularization was studied by confocal laser scanning microscope (CLSM) and flap survival was observed.
RESULTSThe neovascularization and survival of the prefabricated flap was different in the experimental and the control groups. The experimental group was better than the control group.
CONCLUSIONbFGF treatment improved sprouting of the implanted vessel and the prefabricated flap survival.
