Association between genetic polymorphism of the six-transmembrane protein of prostate 2 and obesity in Uygur
10.3760/cma.j.issn.0253-3758.2012.12.010
- VernacularTitle:前列腺六次跨膜蛋白-2基因多态性与维吾尔族人群中心性肥胖的相关性
- Author:
Rui-Mei HAN
1
;
Xiang-Yang ZHANG
;
Zhi-Tao YAN
;
Ju-Hong ZHANG
;
Yan-Ying GUO
;
Hong-Mei WANG
;
Ling ZHOU
;
Nan-Fang LI
Author Information
1. 新疆医科大学研究生院
- Keywords:
Obesity;
Polymorphism,single nucleotide;
Uygur nationality
- From:
Chinese Journal of Cardiology
2012;40(12):1024-1029
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between genetic variations of the six transmembrance protein of prostate 2 (STAMP2) and obesity in Xinjiang Uygur population.Methods A total of 2332 Uygur subjects (1455 obesity and 877 non-obesity control subjects) were included in this casecontrol study based on epidemiological survey.Genetic variations of STAMP2 gene functional region were sequenced.The representative variations selected were genotyped by TaqMan-PCR method.Results Twenty genetic variations,including 14 novel variations,were identified.The genotype distributions of the control group and obesity group were in the Hardy-Weinberg equilibrium (both P ＞ 0.05).The frequency of AA of rs1981529 (67.6％ vs.62.8％,P ＜0.05) and the frequency of G-A-G haplotype (62.4％ vs.58.9％,P＜0.05) in obesity group were significantly higher than that in controls while the frequency of A-G-G haplotype was significantly lower in the obesity patients than that in the control group (17％ vs.20％,P ＜0.05).After adjusting age,sex,smoking and drinking,logistic regression analysis showed that the AA genotype of rs1981529 (OR:1.276,95％ CI:1.049-1.552;P ＜ 0.05) and the G-A-G haplotype (OR:1.356,95％ CI:1.007-1.862,P ＜ 0.05) were the independent risk factors for obesity in this cohort.Conclusion The AA genotype of rs1981529 and G-A-G haplotype are associated with obesity in Uygur population of Xinjiang.
