The effect of catheter based renal symthetic denervation on renin-angiotensin-aldosterone system in patients with resistant hypertension
10.3760/cma.j.issn.0253-3758.2013.01.002
- VernacularTitle:经皮肾脏交感神经射频消融术对顽固性高血压患者肾素血管紧张系统的影响
- Author:
Li WANG
1
;
Cheng-Zhi LU
;
Xin ZHANG
;
Di LUO
;
Bin ZHAO
;
Xiang YU
;
Da-Sheng XIA
;
Xin CHEN
;
Xiang-Dong ZHAO
Author Information
1. 300192,天津医科大学一中心临床学院
- Keywords:
Hypertension;
Catheter ablation;
Renin-angiotensin system
- From:
Chinese Journal of Cardiology
2013;41(1):3-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective to explore the effect of catheter based renal symthetic denervation on reninangiotensin-aldosterone system(RAAS)and blood pressure reduction in patients with resistant hypertension.and assess the validity and security of the treatment.Methods Ten patients with resistant hypertension from June 2011 to December 2011 were retrospectively reviewed,and then all of 10 patients screened for eligibility were allocated to renal denervation.Primary endpoints were changes of office blood pressure at 1week,1,3 and 6 months after procedure.We assessed the effectiveness of renal sympathetic denervation with heart rate (HR),renin activity (PRA),angiotensin Ⅱ (Ang Ⅱ),aldosterone(Ald),and creatinine(Cr)before and 2 weeks after procedure.Results Office blood pressure after catheter-based renal denervation decreased by 22.8/9.1 mm Hg(1 mm Hg =0.133 kPa),34.8/14.7 mm Hg,42.6/20.7 mm Hg,43.2/21.6 mm Hg,at 1 week,1,3 and 6 months,respectively(P ＜ 0.001).Meanwhile,the level of PRA,Ang Ⅱ,Alddecreased by (1.11±0.89)ng· ml-1 · h-1(P=0.003),(17.06±13.82) ng/L (P=0.004),(404.5 ±285.8) ng/L (P =0.002),respectively； and heart rate decreased by 5.1 bpm (P =0.002).However,the Cr level and eGFR did not change significantly (P ＞ 0.05).Conclusion Catheter-based renal sympathetic denervation can reduce the level of renin activity,angiotensin Ⅱ and aldosterone,and causes substantial and sustained blood-pressure reduction.
