Reduced circulating endothelial progenitor cells is a risk factor of coronary slow flow.
- Author:
Quan-zhong LI
1
;
Jin-jie HAN
;
Hua CHEN
;
Xin-ling MO
;
Zhong-hua XIA
;
Zong-jie QIAN
Author Information
- Publication Type:Journal Article
- MeSH: Blood Circulation; Blood Flow Velocity; Case-Control Studies; Cell Count; Cells, Cultured; Coronary Angiography; Coronary Vessels; physiopathology; Female; Humans; Male; Middle Aged; Risk Factors; Stem Cells; cytology
- From: Chinese Journal of Cardiology 2013;41(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore if reduced number of circulating endothelial progenitor cells (EPCs) is a risk factor for patients with coronary slow flow (CSF).
METHODSThirty patients with CSF and 30 age and gender matched control subjects with normal coronary angiography were included in the study. Mononuclear cells were isolated from peripheral blood by Ficoll density gradient centrifugation and plated on fibronectin-coated culture dishes. EPCs were characterized as adherent cells double positive for DiI-AcLDL-uptake and lectin-binding by converted fluorescence microscope (×200).
RESULTSSmoking, diabetes mellitus, hypertension and the levels of plasma lipoprotein profile were similar between the two groups (all P > 0.05). The number of EPCs was significantly lower in patients with CSF compared with control subjects (35.7 ± 5.9 vs.53.2 ± 5.9, P < 0.01). TIMI frame counts was correlated with circulating EPCs number (OR = 0.424, 95%CI 0.358 - 0.621, P < 0.01) and not associated with gender, age, smoking, diabetes mellitus, hypertension and the levels of plasma lipoprotein profile.
CONCLUSIONDecreased circulating EPCs is an independent risk factor for CSF.
