Reduced circulating endothelial progenitor cells is a risk factor of coronary slow flow
10.3760/cma.j.issn.0253-3758.2013.01.010
- VernacularTitle:循环内皮祖细胞与冠状动脉慢血流的关系
- Author:
Quan-Zhong LI
1
;
Jin-Jie HAN
;
Hua CHEN
;
Xin-Ling MO
;
Zhong-Hua XIA
;
Zong-Jie QIAN
Author Information
1. 541001,桂林医学院附属医院心内科
- Keywords:
Coronary artery disease;
Coronary angiography;
Endothelial cells
- From:
Chinese Journal of Cardiology
2013;41(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore if reduced number of circulating endothelial progenitor cells (EPCs) is a risk factor for patients with coronary slow flow (CSF).Methods Thirty patients with CSF and 30 age and gender matched control subjects with normal coronary angiography were included in the study.Mononuclear cells were isolated from peripheral blood by Ficoll density gradient centrifugation and plated on fibronectin-coated culture dishes.EPCs were characterized as adherent cells double positive for DiI-AcLDLuptake and lectin-binding by converted fluorescence microscope (× 200).Results Smoking,diabetes mellitus,hypertension and the levels of plasma lipoprotein profile were similar between the two groups (all P ＞ 0.05).The number of EPCs was significantly lower in patients with CSF compared with control subjects (35.7 ± 5.9 vs.53.2 ± 5.9,P ＜ 0.01).TIMI frame counts was correlated with circulating EPCs number (OR =0.424,95％ CI 0.358-0.621,P ＜ 0.01) and not associated with gender,age,smoking,diabetes mellitus,hypertension and the levels of plasma lipoprotein profile.Conclusion Decreased circulating EPCs is an independent risk factor for CSF.
