Association between serum YKL-40 levels and endothelial function in hypertensive patients
10.3760/cma.j.issn.0253-3758.2013.02.009
- VernacularTitle:高血压患者血清人软骨糖蛋白水平变化及其与内皮功能的相关性研究
- Author:
Ying-Ying DIAO
1
;
Qian-Zhou L(U)
;
Chang-Sheng YANG
;
Duo WEI
Author Information
1. 复旦大学附属中山医院药剂科
- Keywords:
Hypertension;
YKL-40(human cartilage glycoprotein-39);
Endothelium,vascular
- From:
Chinese Journal of Cardiology
2013;41(2):121-125
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum YKL-40 levels and endothelial function in patients with essential hypertension (EH).Method Sixty EH patients [34 male,aged between 43-76 years,mean(59 ±7)years]and 30 healthy subjects [17 male,mean age (57 ±5) years] were enrolled in this study.Serum YKL-40 levels were measured by enzyme immunoassay (ELISA).Endothelial function [endothelin-1 (ET-1),nitric oxide (NO),flow-mediated dilatation (FMD)] was also measured.EH patients were further divided to no metabolic syndrome and metabolic syndrome group.Results Serum uric acid,ET-1,hs-CRP were significantly higher while serum NO,FMD and NMD were significantly lower in EH group than in control group (all P ＜ 0.05).YKL-40 was significantly higher in EH group than in the control group [51.7 (35.6-341.9) μg/L vs.33.2 (23.3-167.3) μg/L,P ＜ 0.05] and significantly higher in EH patients with metabolic syndrome than in EH patients without metabolic syndrome(152.3 μg/L vs.94.2 μg/L,P ＜0.05).In this cohort,serum YKL-40 level was positively correlated with SBP,DBP,BMI,TG and hsCRP(r =0.360,0.303,0.281,0.216,0.530,all P ＜ 0.05) but not correlated with FMD,ET-1 and NO (all P ＞ 0.05).Conclusions Serum YKL-40 levels are increased compared to normal controls and positively correlated with blood pressure level but not with endothelial function parameters in hypertensive patients.Serum YKL-40 level might thus be used as a biomarker reflecting inflammation status other than endothelium function in hypertensive patients.
