The expression and clinical implication of plasma miR-328 in patients with atrial fibrillation.
- Author:
Xi WANG
1
;
Chun-guang QIU
;
Zhen-wen HUANG
;
Zhan-ying HAN
;
Wen-jie LU
;
Xiao-jie CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Atrial Fibrillation; blood; Case-Control Studies; Female; Humans; Male; MicroRNAs; blood; Middle Aged
- From: Chinese Journal of Cardiology 2013;41(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the expression and clinical implication of plasma miR-328 in patients with atrial fibrillation (AF).
METHODSFifty-eight patients with AF (AF group: 17 paroxysmal AF, 21 persistent AF, and 20 permanent AF) and 15 healthy volunteers (Control group) were included. General clinical data and related biochemical parameters were collected. Plasma miR-328 levels were detected with quantitative real-time polymerase chain reaction (qRT-PCR) analysis. The correlation between plasma miR-328 and AF risk factors was analyzed.
RESULTS(1) Compared with the control group, the expression level of plasma miR-328 was significantly elevated in AF group (fold 7.72 ± 9.32) (P < 0.05). (2) In AF group, the expression of plasma miR-328 was significantly different in different type of AF[paroxysmal AF with (1.98 ± 0.81), persistent AF with (6.57 ± 5.82) and permanent AF with (13.47 ± 12.29)] (P < 0.05), and which was increased in proportion to the duration of AF. (3) There was a positive correlation between plasma miR-328 level and left atrial diameter in the AF group (r = 0.310, P < 0.05).
CONCLUSIONmiR-328 expression is significantly increased in patients with AF, which may be involved in the atrial remodeling process of AF.
