The expression and clinical implication of plasma miR-328 in patients with atrial fibrillation
10.3760/cma.j.issn.0253-3758.2013.02.010
- VernacularTitle:血浆miR-328在心房颤动中的表达水平及其临床意义
- Author:
Xi WANG
1
;
Chun-Guang QIU
;
Zhen-Wen HUANG
;
Zhan-Ying HAN
;
Wen-Jie LU
;
Xiao-Jie CHEN
Author Information
1. 450052,郑州大学第一附属医院心内科
- Keywords:
Atrial fibrillation;
microRNAs;
Polymerase chain reaction
- From:
Chinese Journal of Cardiology
2013;41(2):126-129
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the expression and clinical implication of plasma miR-328 in patients with atrial fibrillation (AF).Methods Fifty-eight patients with AF (AF group: 17 paroxysmal AF,21 persistent AF,and 20 permanent AF) and 15 healthy volunteers (Control group) were included.General clinical data and related biochemical parameters were collected.Plasma miR-328 levels were detected with quantitative real-time polymerase chain reaction (qRT-PCR) analysis.The correlation between plasma miR-328 and AF risk factors was analyzed.Results (1) Compared with the control group,the expression level of plasma miR-328 was significantly elevated in AF group (fold 7.72 ± 9.32) (P ＜ 0.05).(2) In AF group,the expression of plasma miR-328 was significantly different in different type of AF [paroxysmal AF with (1.98 ± 0.81),persistent AF with (6.57 ± 5.82) and permanent AF with (13.47 ± 12.29)] (P ＜ 0.05),and which was increased in proportion to the duration of AF.(3) There was a positive correlation between plasma miR-328 level and left atrial diameter in the AF group (r =0.310,P ＜ 0.05).Conclusion miR-328 expression is significantly increased in patients with AF,which may be involved in the atrial remodeling process of AF.
