Association between peroxisome proliferator-activated receptor gene single nucleotide polymorphisms and arterial stiffness in adult Chinese population
10.3760/cma.j.issn.0253-3758.2013.04.006
- VernacularTitle:过氧化物酶体增殖物激活受体基因单核苷酸多态性与动脉僵硬度的关系
- Author:
Ru-Yi XU
1
;
Ping YE
;
Li SHENG
;
Lei-Ming LUO
;
Hong-Mei WU
;
Wen-Kai XIAO
Author Information
1. 海军总医院老年心血管内科
- Keywords:
Arteriosclerosis;
Polymorphisms,single nucleotide;
Peroxisome proliferator-activated receptors
- From:
Chinese Journal of Cardiology
2013;41(4):288-292
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association between single nucleotide polymorphisms(SNPs)of peroxisome proliferator-activated receptor(PPAR) and arterial stiffness in adult Chinese population (＞ 50 years).Methods Cardiovascular risk factors from participants of Beijing epidemiological investigation were analyzed.Carotid-femoral pulse wave velocity (cfPWV) was measured by Complior system.The subjects were divided into normal arterial stiffness group (cfPWV ＜ 12 m/s,n =844) and increased arterial stiffness group (cfPWV ＞ 12 m/s,n =530).Three valid SNPs including rs1053049,rs1800234 and rs8192678 in the PPAR and PPARγCla gene were genotyped by TaqMan allelic discrimination assays.Results The age [(67.9 ±8.8) years vs.(58.0 ±9.7) years],prevalence of hypertension[71.1％ (377/530) vs.30.5％ (257/844)] and diabetes mellitus [21.7％ (115/530) vs.11.0％ (93/844)] were all significantly higher in increased arterial stiffness group than in normal group (all P ＜ 0.05).The frequencies of CC,CT and TT type of rs8192678 [CC:32.2％ (272/844) vs.30.8％ (163/530),CT:48.7％ (411/844) vs.52.1％ (276/530),TT:19.1％ (161/844) vs.17.2％ (91/530)],rs1053049 [CC:55.7％ (470/844) vs.51.3％ (272/530),CT:36.7％ (310/844) vs.39.1％ (207/530),TT:7.6％ (64/844) vs.9.6％ (51/530)] and rs1800234 [CC:88.4％ (746/844) vs.90.4％ (479/530),CT + TT:11.6％ (98/844) vs.9.6％ (51/530)] were similar between the two groups.There was also no association between haplotypes and the increased arterial stiffness in this cohort.Conclusions In this community-based population,we found that aging,hypertension and diabetes mellitus were associated but SNPs of PPAR and PPARγCla were not associated with arterial stiffness.
