Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China.
- Author:
Min ZHOU
1
;
Shao-guang HUANG
;
Huan-ying WAN
;
Biao LI
;
Wei-wu DENG
;
Min LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; China; ethnology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Matrix Metalloproteinase 9; genetics; Middle Aged; Polymorphism, Genetic; Promoter Regions, Genetic; Pulmonary Disease, Chronic Obstructive; genetics
- From: Chinese Medical Journal 2004;117(10):1481-1484
- CountryChina
- Language:English
-
Abstract:
BACKGROUNDThere are many candidate genes for chronic obstructive pulmonary disease (COPD). Matrix metalloproteinase-9 (MMP-9) plays an essential role in tissue remodeling and repair associated with development of COPD. In this study we investigated the correlation between MMP-9 gene polymorphism and COPD susceptibility in the Han population of South China.
METHODSWe examined the frequency of polymorphic genotypes of the MMP-9 promoter (-1562C/T) in 100 COPD patients and 98 healthy smokers by restriction fragment length polymorphism.
RESULTSThe frequencies of polymorphic genotypes in promoters of MMP-9 were C/C 86%, C/T 14% in COPD group; and C/C 98%, C/T 2% in the control group. There were significant differences between the two groups (P < 0.01). The allele frequencies were also significantly different between the COPD group and the control group (C allele frequency: 93% vs 99%, T allele frequency: 7% vs 1%, P < 0.05 respectively).
CONCLUSIONThe genetic polymorphism in promoters of MMP-9 gene is associated with the susceptibility to COPD in the Han population of South China.
